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Protein Biochemistry
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Wnt-C59
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Wnt-C59
Chemical Structure of Wnt-C59
Wnt-C59 from Biorbyt
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Citations:
(11)
Supplier Page
Supplier Page from
Biorbyt for
Wnt-C59
Description
Wnt-C59(C59) is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Wnt-C59
Company
Biorbyt
Price
Pricing Info
Supplier Page
Catalog Number
orb181132
Quantity
10 mM * 1 mL in DMSO, 100 mg, 250 mg, 1000 mg
Molecular Weight
379.45
Formula
C25H21N3O
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Biorbyt
7, Signet Court
Swann Road
Cambridge
,
Cambridgeshire
CB5 8LA
United Kingdom
Phone
: +44(0)1223 815 212
+44(0)1223 280 240 (fax)
+44(0)1223 280 240
Email: info@biorbyt.com
support@biorbyt.com
accounts@biorbyt.com
Company Profile
Website:
https://www.biorbyt.com/
Citations (11)
(1)
Spatially resolved multiomics of human cardiac niches
Nature
July 27, 2023
Kazumasa Kanemaru, James Cranley, Daniele Muraro, Antonio M. A. Miranda, Siew Yen Ho, Anna Wilbrey-Clark, Jan Patrick Pett, Krzysztof Polanski, Laura Richardson, Monika Litvinukova,
et al.
cell culture medium
was replaced with RPMI/
B27
, minus insulin. For the next 2 days, 2 μM
Wnt-C59
(
Biorbyt
,
orb181132
) was added in RPMI/B27, minus insulin. Cells were then cultured in RPMI/
B27
, minus insulin, with media
(2)
Pathogenesis of Cardiomyopathy Caused by Variants in ALPK3, an Essential Pseudokinase in the Cardiomyocyte Nucleus and Sarcomere
Circulation
November 29, 2022
Agarwal R, Wakimoto H, Paulo JA, Zhang Q, Reichart D, Toepfer C, Sharma A, Tai AC, Lun M, Gorham J,
et al
.
with
B27
minus insulin for 2 days (days 1 to 2). Cultures were then treated with 2 μM
Wnt-C59
(
Biorbyt
orb181132
) in RPMI supplemented with
B27
minus insulin for 2 days (days 3 to 5). Cells were maintained in RPMI
(3)
Genome-wide association analyses identify novel Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
Nature Genetics
March 1, 2022
Julien Barc et al.
(GenDEPOT, A0100), 200 μg/ml L-ascorbic acid 2-phosphate (Wako, 321-44823) and 0.5 μM
Wnt-C59
(
Biorbyt
,
orb181132
). Medium was then changed on day 4 and then every other day with RBAI consisting of RPMI supplemented
(4)
Lymphoangiocrine signals promote cardiac growth and repair
Nature
December 1, 2020
Liu X, De la Cruz E, Gu X, Balint L, Oxendine-Burns M, Terrones T, Ma W, Kuo HH, Lantz C, Bansal T,
et al
.
is changed to CDM3. On day 2, medium is changed to CDM3 supplemented with 2 μM of
Wnt-C59
(
Biorbyt
,
orb181132
). Medium is then changed every other day for CDM3 starting on day 4. Contracting cells are noted from
(5)
Cardiac Ischemic Preconditioning Promotes MG53 Secretion Through H
2
O
2
-Activated Protein Kinase C-δ Signaling
Circulation
September 15, 2020
Dan Shan et al.
hours later, the medium was changed to basal medium supplied with 2 μmol/LWnt-
C59
(
Biorbyt
, catalog no.
orb181132
) for another 48 hours. The cells were then maintained in basal medium, changing to fresh media every 48
(6)
Negligible-Cost and Weekend-Free Chemically Defined Human iPSC Culture
Stem Cell Reports
February 1, 2020
Hui-Hsuan Kuo et al.
and on day 2 the medium was changed to CDM3 supplemented with 2 μM Wnt
inhibitor
Wnt-C59
(
Biorbyt
,
orb181132
). The medium was then changed on day 4 and then every other day with CDM3. Contracting cells were noted
(7)
Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicity
Nature protocols
December 1, 2018
Sharma A, McKeithan WL, Serrano R, Kitani T, Burridge PW, Del Álamo JC, Mercola M, Wu JC.
no.
OsrHSA-100
) CHIR99021 (Thermo Fisher Scientific, cat. no. 508306)
Wnt-C59
(
Biorbyt
, cat. no.
orb181132
) Rho kinase (ROCK) inhibitor (Tocris, cat. no. 1254) 0.5 M EDTA (
Thermo Fisher Scientific
, cat.
(8)
Differentiation and Contractile Analysis of GFP-Sarcomere Reporter hiPSC-Cardiomyocytes
Current protocols in human genetics
January 24, 2018
Sharma A, Toepfer CN, Schmid M, Garfinkel AC, Seidman CE.
no. 17504-044) CHIR99021 (Thermo Fisher Scientific, cat. no. 508306)
Wnt-C59
(
Biorbyt
, cat. no.
orb181132
) 6-well
tissue culture
-treated plates Standard
cell culture
laminar flow hood mTeSR1 medium (
StemCell Technologies
(9)
Chemically Defined Culture and Cardiomyocyte Differentiation of Human Pluripotent Stem Cells
Current protocols in human genetics
October 6, 2015
Burridge PW, Holmström A, Wu JC.
cat. no.
orb154612
), 600 μL aliquots at 10 mM in
DMSO
, store at −20 °C
Wnt-C59
(
Biorbyt
, cat. no.
orb181132
), 200 μL aliquots at 10 mM in
DMSO
, store at −20 °C
L-lactic acid
(Wako Chemicals USA, cat. no. 129-02666),
(10)
Developmental changes in integrin beta-subunits in rat cerebral cortex
Neuroscience letters
October 3, 1997
Cousin B, Leloup C, Pénicaud L, Price J.
(11)
Strain-related differences in airway smooth muscle and airway responsiveness in the rat
The American review of respiratory disease
October 1, 1991
D H Eidelman, G U DiMaria, S Bellofiore, N S Wang, R D Guttmann, J G Martin
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Wnt-C59 from Biorbyt
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